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Index > Protein center > CCND2(Gene name) > Human
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  • CCND2 (Gene name),
  • G1/S-specific cyclin-D2 (Protein name ),  CCND2_HUMAN from NCBI database.
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  • Gene name:
    CCND2;
    Protein name:
    G1/S-specific cyclin-D2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.
    Function:
    Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    Subcellular Location:
    Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
    Protein Attributes:
    Sequence length:
    289
    Sequence:
    50:
    MELLCHEVDP | VRRAVRDRNL | LRDDRVLQNL | LTIEERYLPQ | CSYFKCVQKD | 
    100:
    IQPYMRRMVA | TWMLEVCEEQ | KCEEEVFPLA | MNYLDRFLAG | VPTPKSHLQL | 
    150:
    LGAVCMFLAS | KLKETSPLTA | EKLCIYTDNS | IKPQELLEWE | LVVLGKLKWN | 
    200:
    LAAVTPHDFI | EHILRKLPQQ | REKLSLIRKH | AQTFIALCAT | DFKFAMYPPS | 
    250:
    MIATGSVGAA | ICGLQQDEEV | SSLTCDALTE | LLAKITNTDV | DCLKACQEQI | 
    289:
    EAVLLNSLQQ | YRQDQRDGSK | SEDELDQAST | PTDVRDIDL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586h
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    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586m
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    96T
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    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586p
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    96T
    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586b
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    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586c
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    ELISA Kit for Human G1/S-specific cyclin-D2
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    E0586r
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    Packing:
    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
    Cat.:
    U0586c
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    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
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    U0586b
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    Packing:
    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
    Cat.:
    U0586m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
    Cat.:
    U0586r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
    Cat.:
    U0586h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human G1/S-specific cyclin-D2
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    Packing:
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    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Cat.:
    P0586Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Cat.:
    P0586Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Polyclonal Antibody for Human G1/S-specific cyclin-D2
    Cat.:
    P0586Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Monoclonal Antibody for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2
    Protein for Human G1/S-specific cyclin-D2

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    References
    1. 1.
      "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins."
      Xiong Y. , Menninger J. , Beach D. , Ward D.C.
      Genomics13:575-584(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines."
      Palmero I. , Holder A. , Sinclair A.J. , Dickson C. , Peters G.
      Oncogene8:1049-1054(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      Miyajima N.
      Submitted (1993-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      NIEHS SNPs program
      Submitted (2002-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-268
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
      tissue: Uterus.
    10. 10.
      "Genomic organization, chromosomal localization, and independent expression of human cyclin D genes."
      Inaba T. , Matsushime H. , Valentine M. , Roussel M.F. , Sherr C.J. , Look A.T.
      Genomics13:565-574(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240
      tissue: Placenta.
    11. 11.
      The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute
      Submitted (1998-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-140 (ISOFORM 2)
      tissue: Glioblastoma.
    12. 12.
      "Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition."
      Wang Z. , Xie Y. , Zhang L. , Zhang H. , An X. , Wang T. , Meng A.
      Cell Struct. Funct.33:171-183(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK4;SUBCELLULAR LOCATION
    13. 13.
      "Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization."
      Denicourt C. , Legault P. , McNabb F.A. , Rassart E.
      Oncogene27:1253-1262(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORM 2);ALTERNATIVE SPLICING
    14. 14.
      "F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation."
      Chen B.B. , Glasser J.R. , Coon T.A. , Zou C. , Miller H.L. , Fenton M. , McDyer J.F. , Boyiadzis M. , Mallampalli R.K.
      Blood119:3132-3141(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY SCF(FBXL2)
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